Cogitating on Statin studies in particular, with the rate of Myopathy.
Seems I read that the drug companies were very particular to eliminate all subjects that had any history of muscle problems. And then claim that Statin Myopathy is VERY rare. Yet other reading tells me that in clinical practices, the SM rate is about 30%. That 30% would drop out of any statistics re: efficacy of the drug. Hmmmm, I wonder what the heart attack rate is in the Myopathy Group? (anecdote: In my group of ONE, I have myopathy without statins, and had a herat attack at 49)
So, anybody out there in the interwebs know of any study, statin or other, where stats are published for the drop out group? Or is it quite likely that there is a HUGE and very common selection bias?
I'm saying there are three groups. This placebo group, and active group, and the group of dropouts. Dropouts have such a problem that the drug can't be taken, and eliminating that last group would be selecting out the most likely to have heart attacks?
But the studiers would say "Of course they have heart attacks, they weren't on our wonder drug". But if that 3rd group has a heart attack rate higher than the control group....
(I know I repeat myself, but I want to eliminate misunderstanding. Maybe I should form a 3rd group- Those who agree, those that disagree, and those that can't understand. ;) )
Seems I read that the drug companies were very particular to eliminate all subjects that had any history of muscle problems. And then claim that Statin Myopathy is VERY rare. Yet other reading tells me that in clinical practices, the SM rate is about 30%. That 30% would drop out of any statistics re: efficacy of the drug. Hmmmm, I wonder what the heart attack rate is in the Myopathy Group? (anecdote: In my group of ONE, I have myopathy without statins, and had a herat attack at 49)
So, anybody out there in the interwebs know of any study, statin or other, where stats are published for the drop out group? Or is it quite likely that there is a HUGE and very common selection bias?
I'm saying there are three groups. This placebo group, and active group, and the group of dropouts. Dropouts have such a problem that the drug can't be taken, and eliminating that last group would be selecting out the most likely to have heart attacks?
But the studiers would say "Of course they have heart attacks, they weren't on our wonder drug". But if that 3rd group has a heart attack rate higher than the control group....
(I know I repeat myself, but I want to eliminate misunderstanding. Maybe I should form a 3rd group- Those who agree, those that disagree, and those that can't understand. ;) )
via JREF Forum http://forums.randi.org/showthread.php?t=265668&goto=newpost
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