Calorie restriction can help you live longer

One of those things one reads about. One of those things that promise a lot but are probably bull? Except not, in this case: not bull, fact. Calorie restriction, intentionally starving the body, does help you live longer.

An informative post* in another thread set me thinking that this is something I must read up on, learn some more about -- and perhaps, if it seems entirely genuine, as well as easily doable, incorporate into my lifestyle? Except one makes these must-read lists, and never gets to actually following up on them.

Best to get a discussion going on this. Living longer seems like a good idea, no?

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* The post I was refering to:

Quote:

Originally Posted by Louden Wilde (Post 13299462) I mean overall life/health-span (the latter being the the portion of an organisms life in which they are reasonably good health, e.g. mobile, functional). Calorie restriction had been shown to extend life/health span in rats as far back as the 1930s - it has since been shown to work in pretty much every organism tested. Obviously we can't in test this in humans as rigorously as we'd like (i.e. by by going through the whole lifespan), but biomarkers suggest this is the case with us as well. An even better biomarker than telomeres (IMO, and others) is the epigenetic clock Note this method can also estimate when you are likely to die Evidence is increasing for those other two. When I left academia a few years ago (where I had done some environment/epigenetics work), I spent a year at a biotech working in this area, and so got pretty up on the literature. Just finishing work and frankly don't feel like digging all the refs up right now. Worth noting that these same stressors can have protective effects in other areas: e.g. Protection against renal ischemia-reperfusion injury through hormesis? Dietary intervention versus cold exposure Dietary restriction (DR) and fasting (FA) induce robust protection against the detrimental effects of renal ischemia-reperfusion injury (I/RI). Several mechanisms of protection have been proposed, such as hormesis. Hormesis is defined as a life-supporting beneficial effect resulting from the cellular responses to single or multiple rounds of (mild) stress. The cold exposure (CE) model is a stress model similar to DR, and has been shown to have hormetic effects and has proved to increase longevity. CE is considered to be the most robust method to increase metabolism through activation of brown adipocytes. BAT has been considered important in etiology of obesity and its metabolic consequences.

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